技术团队 —首席顾问

首席研发顾问: 刘灿荣 教授

简历:
为美国临床生化学院院士暨美国自由基生物医学会之院士,曾任美国旧金山州立大学终身职正教授及长庚大学医学生物技术暨检验学系创系系主任兼教授,现职为台北医学大学顾问教授及富氢生技公司研发顾问教授

    • 国立台湾大学农学士
    • 美国加州柏克莱大学博士
    • 美国加州大学旧金山分校博士后研究
    • 长庚大学生物医学暨检验学系创系主任兼教授
    • 台北医学院附属医院癌症中心转译研究室顾问教授

1. 持续有效率创新、精进质子交换膜运用方式;
2. 开发具原创性的设计及新型制氢系统;
3. 研发各式氢气运用于医学及生物体的方法学,以此三方面为研发目标。

Personal data

Born: August 29, 1938

Sex: Male

Address: Translational Research Lab. of Cancer Center, Taipei Medical

University Hosp. 7F, First Medical Building, 252, Wu-Hsing St.,

Taipei, Taiwan 110

Phone: (+886 )-2-2737-2181 ext. 3782 ; (+886)-2-8789-0554

Fax:(+886)-2-8789-0554

e-mail: tzliu@tmuh.org.tw

Education

B. S., National Taiwan University (1957-1961)

M. S. / Ph. D., University of California at Berkeley (1966-1971)

Professional experience

Postdoctoral Fellow, University of California, San Francisco (1971-1973)

NIH Postdoctoral Training for Clinical Pathology, University of California, San Francisco

(1973-1975)

Assistant Clinical Chemist, R & D Division, Clinical Laboratories, San Francisco General

Hospital and Department of Clinical Pathology, University of California, San Francisco

(1975-1978)

Assistant Professor, Center for Advanced Medical Technology, San Francisco State University

(1978-1981)

Associate Professor, Center for Advanced Medical Technology, San Francisco State University

(1981-1985)

Professor, Center for Advanced medical Technology, San Francisco State University

(1985-1989)

Professor/Chair, School of Medical Technology, Chang-Gung University (1989-1997)

Professor/Director, Department of Medical Research, Yuan’s General Hospital, Kaohsiung

(1997-2000)

Professor, Department of Medical Technology, Fooyin Institute of Technology (2000- 2001)

Professor, School of Medical Technology and Graduate Institute of Medical Biotechnology,

Chang Gung University, Taoyuan (2002-2009)

Consultant/Professor, Translational Research Lab. of Cancer Center, Taipei Medical University

Hospital, Taipei, Taiwan (2009 to present)

Editorial experience

Editor-in-Chief, “ Journal of Biomedical & Laboratory Sciences ” 1997-2005

Editorial Board Member, “ American Journal of Biomedical Sciences ” 2009-2011

Editorial Board Member, “ TUNGS’ Medical Journal ” 2007-2009

Editorial Board Member, “ Medical Journal of South Taiwan ” 2006-present

Honors

1960- President’s Award for outstanding undergraduate student (Book Scroll Award)

1973-74- NIH postdoctoral trainee in Clinical Pathology

1980- Appointed Research Associate at Cancer Research Institute, University of California at

San Francisco

1980- Elected a member of National Academy of Clinical Biochemistry

1980-81- Recommended for Accelerated Tenure and Promotion by Clinical Science HRTP

Committee and approved by the University Promotion Committee

1982- Clinical Chemist Recognition Award, American Association for Clinical Chemistry

1984- Invited to serve as consultant for Taipei Institute of Pathology

1984- Elected a member of the Association of Clinical Scientists

1986- Meritorous Performance and Professional Promise Award, San Francisco State University

1993- Best Poster Award (one of the fifteen among > 700 posters) XV International Congress

of Clinical Chemistry, Melbourne, Australia. Nov. 14-19

1999- Beckman- Coulter Award- International presentation

2000- Outstanding Contributions to Clinical Chemistry Award, Northern California Chapter,

American Association for Clinical Chemistry

2004- Sole invited speaker from Taiwan to attend International Symposium on Health-

Beneficial Effects of Prunus Mume, Seoul, Korea

2005- Distinguish Services Award, Taiwan Society of Laboratory Medicine

1997-2005- Editor-in-Chief, Jounal of Biomedical and Laboratory Science

2003-2005- President, Society for Free Radical Research (Taiwan)

2006- Listee of Leading Scientists of the world , International Biographical Center, Cambridge

England

2013-Special Achievement Award, 2013 Biennial SFFR-Asia Meeting, Chang Gung

University, Taiwan

2013-Inducted to the Fellow status of the Society of Free Radical Biology and Medicine

(F-SFRBM) (First inductee from Asia)

Membership in Professional Societies

Society for Free Radical Biology and Medicine (SFRBM)

Association of Clinical Scientists

National Academy of Clinical Biochemistry

American Association for Clinical Chemistry

Formosan Medical Association

Specialty

Clinical and Nutritional Biochemistry, Free Radical Biology & Medicine, Tumor Cell Biology,

Clinical and Environmental Toxicology

Research Interests

  1. Role of intracellular oxidative stress status (IOSS) in the modulation of metastatic propensity of Human hepatoma cell lines with varying degrees of differentiation.
  2. Role of c-Myc expression and its translocation to the nucleus in the modulation of IOSS in HCC cells.
  3. Direct visualization of endogenous ROS, GSH distribution, lipid peroxidation and mitochondrial alcium homeostasis in the modulation of oxidant-induces apoptotic cell death in HCC cells using confocal microscopy and flowcytometry.
  4. Proteomic characterization of oxidatively modified proteins relevant to folate deficiency-induced apoptosis in Hep G2 cells.
  5. Proteomic discovery of protein biomarkers relevant to differentiation status of hepatoma cells.
  6. Study on the role of oxidative-nitrosative stress, glutathione redox imbalance, lipid peroxidation and mitochondrial calcium overload in the PDT of BPD-MA-induced apoptosis.
  7. Hair multi-element analysis by ICP/MS and its clinical applications.
  8. Probe-based ultraweak chemiluminescence method for analyzing oxygen-derived free radicals.
  9. Biomarkers discovery for chemo- and radioresistance acquisition
  10. Folate status and cancer progression/drug &RT resistance acquisition
  11. Biomarkers discovery in the sera of HCC patients
  12. Hydrogen Medicine

(A)REFEREED PAPER
※ Denoted publication related to the fields of free radical, redox biology & antioxidants

※1. T. Z. Liu, H. M. Oien, and E. L. R. Stokstad (1971) The effect of esradiol- 17- beta and vegetable oil on the hydroxylation of protocollagen. Proc Soc Exptl Biol and Med 137:207. (SCI IF= 2.8; Rank= 39.7%)

※2. T. Z. Liu, J. T. Shen, and H. F. Ganong (1974) Evidence for superoxide anion involvement in dopamine-beta-hydroxylase system. Proc Soc Exptl Biol and Med 146:3. (SCI IF= 2.8; Rank = 39.7%)

3. R. S. Bhatnagar, S. S. R. Rapaka, T. Z. Liu, and S. M. Wolfe (1972) Hydralazine- induced disorder in collagen biosynthesis. Biochem Biophys Acta 271:125. (SCI IF= 4.13; Rank= 18.1%)

4.T. Z. Liu, and R. S. Bhatnagar (1973) Inhibition of protocollagen proline hydroxylase by dilantin. Proc Soc Exptl Biol and Med 142:253. (SCI IF= 2.8; Rank= 39.7%)

※5. R. S. Bhatnagar, and T. Z. Liu (1973) Evidence for free radical involvement in the hydroxylation of proline: inhibition by nitro blue tetrazolium. FEBS Letters 26:31. (SCI IF= 3.58 Rank= 2.50%)

6. T. Z. Liu, J. T. Shen, and H. F. Loken (1974) Inhibition of dopamine- beta- hydroxylase by hydralazine. Proc Soc Exptl Biol and Med 145:294. (SCI IF= 2.8; Rank= 39.7%)

※7. T. Z. Liu, H. Wong, and S. B. Shohet (1974) A rapid and simple radioassay for thymine 7-hydorxylase. Anal Biochem 62: 408. (SCI IF=2.58; Rank=34.7%)

8. W. Levinson, R. S. Bhatnagar, and T. Z. Liu (1975) Loss of ability to synthesize collagen in fibroblast transformed by Rous sarcoma virus. J Natl Cancer Inst 55:807. (SCI IF= 14.3; Rank= 3.6%)

※9.T. Z. Liu, and H. Khayam-Bashi (1977) Direct acid ferric reduction by catecholamine and their related metabolites: Interference with the quantitation of uric acid. Clin Chem 23:1122. (SCI IF= 7.15; Rank= 3.2%)

※10. T. Z. Liu, and H. Kyaym-Bashi (1977) Interference of sodium azide with the quantitation of serum uric acid by the direct acid ferric reduction procedure. Clin Chem 23:581. (SCI IF= 7.15; Rank= 3.2%)

11. S. S. R. Rapaka, R. W. Parr, T. Z. Liu, and R. S. Bhatnagar (1977) Biochemical Basis of skeletal defects induced by hydralazine: Inhibtion of collagen and

1

(A)REFEREED PAPER
※ Denoted publication related to the fields of free radical, redox biology & antioxidants

secretion in embryoic cartilage in vitro. Teratology 15:185. (SCI IF= 3.15; Rank= 28.2%)

12. H. Khayam-Bashi, and T. Z. Liu (1977) Serum magnesium quantitation using a centrifugal analyzer. Clin Chem 23:289. (SCI IF= 7.15; Rank= 3.2%)

13. T. Z. Liu, and H. Khayam-Bashi (1978) Fluorometric quantitation of glutamine in cerebrospinal fluid. Clin Chem 24:997. (SCI IF=7.15; Rank=3.2%)

14. T. Z. Liu (1979) Thymol is a suitable preservation for uric acid standards in the ruicase technique. Clin Chem 25:336. (SCI IF= 7.15; Rank= 3.2%)

15. T. Z. Liu (1979) Is sodium azide preservative a carcinogen? Clin Chem 25:1514. (SCI IF= 7.15; Rank= 3.2%)

16. T. Z. Liu, H. Khayam-Bashi, and R. S. Bhatnagar (1979) Inhibition of creatine kinase activity and alteration of electrophoretic mobility by palladium J Environ Pathol and Toxicol 2:907. (SCI IF= 0.92; Rank= 85.9 %)

※17. T. Z. Liu, S. D. Lee, and R. S. Bhatnagar (1979) Toxicity of palladium. Toxicol Letters 4:469. (SCI IF= 3.15; Rank= 29.4%)

18. T. Z. Liu, L. Y. Chou, and M. H. Humphreys (1979) Inhibition of alkaline phsophatase by palladium. Toxicol Letters 4:433. (SCI IF= 3.15; Rank= 29.4%)

※19. T. Z. Liu, and H. Khayam-Bashi (1979) Positive interference of catecholamine metabolites with the quantitation of urinary uric acid by the direct acid ferric reduction method. Clin Chem 25:788. (SCI IF= 7.15; Rank= 3.2%)

20. T. Z. Liu, and H. Khayam-Bashi (1980) Fluorometric quantitation of glutamine in cerebrospinal fluid. Clin Chem 26:700. (SCI IF= 7.15; Rank= 3.2%)

21. T. Z. Liu (1980) Presence of atypical creatine kinase isoenzyme in serum of a patient with congestive heart failure. Chine Med J 27:576. (Non-SCI)

22. T. Z. Liu, J. T. Shen, Y. N. Lee, and R. S. Shohet (1980) Atypical cathode- migrating creatine kinase isoenzyme and human breast carcinoma. Clin Chem 26:1765. (SCI IF= 7.15; Rank= 3.2%)

※23.T. Z. Liu, and H. K. Oka (1980) Spectrophotometric screening method for acetaminophen in serum and plasma. Clin Chem 26:69.(SCI IF= 7.15; Rank= 3.2%)

24. T. Z. Liu, and R. S. Bhatnagar (1980) Inhibition of aldolase by palladium. Bull 2

(A)REFEREED PAPER
※ Denoted publication related to the fields of free radical, redox biology & antioxidants

Environ Contam and Toxciol 24:484. (SCI IF= 0.92; Rank= 85.9 %)

※25.T. Z. Liu, and H. Khayam-Bashi (1981) thymol preservative interferes with quantitation of serum uric acid by the direct acid ferric reduction method. Clin Chem 27:1145. (SCI IF= 7.15; Rank= 3.2%)

※26. T. Z. Liu, N. Chin, D. Kiser, and W. N. Bigler (1982) A specific spectrophotometry of serum ascorbate by use of ascorbate oxidase. Clin Chem 28:2225. (SCI IF= 7.15; Rank= 3.2%)

27. T. Z. Liu, and W. N. Bigler (1983) Unusual creatine kinase isoenzyme pattern associated with a case of acute pancreatitis. Clin Chem 29:597. (SCI IF= 7.15; Rank= 3.2%)

28. T. Z. Liu (1983) Clincial utility of gama-glutamyl transferase and isoenzymes. Med Today 10:629. (Non-SCI)

29. T. Z. Liu (1983) Unusual high proportion of creatine kinase MB isoenzyme, evidently of nonmyocardial origin in serum of a patient with cancer of the prostate. Clin Chem 29:2127. (SCI IF= 7.15; Rank= 3.2%)

30. T. Z. Liu, and W. N. Bigler (1983) A better method for eliminating salicylate interference in acetaminophen measurement. Clin Chem 29:590. (SCI IF= 7.15; Rank= 3.2%)

31. T. Z. Liu (1984) Clinical application of ligandin (Glutathione s-transferase) Med Today 11:3. (Non-SCI)

32. T. Z. Liu (1984) Therapuetic drug monitoring (TDM): Factors influencing serum drug concentration. Med Today 11:429. (Non-SCI)

33. T. Z. Liu, Adber-Rahim Qawasmeh, and Rajar A. Mabar (1984) A new variant of lactate dehydrogenase isoenzyme in human saliva. Enzyme 32:232. (SCI)

34. T. Z. Liu (1984) Differed substrate reactivity with human and porcine amylase: A potential source of error in serum amylase determination. J Formosan Med Assoc 83:1190. (SCI IF= 1.0; Rank= 51.7%)

35. T. S. Ho, and T. Z. Liu (1984) Acetaminophen poisoning and treatment. Med Today 11:71. (Non-SCI)

※36.T. Z. Liu, and J. S. Skale (1985) Rapid spectrophotometric method for the quantitation of serum acetaminophen. J Formosan Med Assoc 84:693. (SCI IF=

3

(A)REFEREED PAPER
※ Denoted publication related to the fields of free radical, redox biology & antioxidants

1.0; Rank= 51.7%)

37. T. Z. Liu (1985) Hemoglobin A. C.: A quantitative index for diabetic control. Med Today 12:100. (Non-SCI)

38. T. Z. Liu, and C. Y. Yuan (1985) Severe depression of serum cholinesterase activity associated with two cases of hepatic encephalopathy. Clin Chem 31:1570. (SCI IF=7.15; Rank= 3.2%)

※39.T. Z. Liu (1986) Hyperuricemia associated with sickle cell anemia may compensate for chronic antioxidant deficiency. Clin Chem 32:560. (SCI IF= 7.15; Rank=3.2%)

40. T. Z. Liu (1986) Human chorioric gonadotropin: a review of methodologies. Med Today 13:366. (Non-SCI)

41. T. Z. Liu (1987) Apparent relation between an atypical cathodically migrating creatine kinase isoenzyme and disseminated malignancy. J Formosan Med Assoc 86:11. (SCI IF= 1.0; Rank= 51.7 %)

42. T. Z. Liu, and Wei JS (1990) Diagonstic efficacy of a monoclonal antibody-based immunoenzy-mometric assay for cardiac specific creatine kinase MB isoenzyme. J Formosan Med Assoc 89:259. (SCI IF= 1.0; Rank= 51.7 %)

43. J. S. Huang, T. Z. Liu, and R. S. Bhatnagar (1990) Creatine kinase and Lactate dehydrogenase isoenzyme patterns in normal and diseased gingival fibroblasts. J Formosan Med Assoc 89:126. (SCI IF= 1.0; Rank= 51.7 %)

44. T. Z. Liu (1990) Toxicity of palladium: Effects on metablically important enzymes. Proc Sympo Health Risk Environ Occuptional Life Style Hazards. IBS, Acad Sinica Taipei, Taiwan ROC pp. 231-251. (Non-SCI)

※45. D. Y. T. Chiu, S. L. Ho, T. Z. Liu, E. Vichinsky, and B. H. Rubin (1990) Vitamin C deficiency in patients with sickle cell anemia. J Hematol Oncology 12,262. (SCI IF= 4.46; Rank= 22.4 %)

46. T. Z. Liu, and C. F. Sun (1990) Laser nephelometric determination of protein in urine and cerebrospinal fluid. J Formosan Med Assoc 89:1067. (SCI IF= 1.0; Rank= 51.7 %)

47. T. Z. Liu, and J. S. Wei (1991) Rapid laser nephelometric quantitation of amylase activities in serum and urine. J Formosan Med Assoc 90:217. (SCI IF= 1.0; Rank=

4

(A)REFEREED PAPER
※ Denoted publication related to the fields of free radical, redox biology & antioxidants

51.7 %)

  1. Chiu DTY. Zuo L, Chen E. Chao L, Louie E, Lubin B, Liu TZ, Du CS. (1991) Two commonly occurring nucleotide base substitutions in Chinese G6PD variants Biochem Biophys Res Comm 180(2):988-993. (SCI IF= 2.41; Rank= 54.2 %)
  2. Zuo L, Chen EY, Chang CN, Du CS, Liu TZ, Chiu DTY. (1991) A new mutation responsible for severe G6PD deficiency in two ethnic Chinese with different clinical presentations: Determination by a direct PCR sequencing technique. International J. Hematology 55:33-44. (SCI IF= 1.68; Rank= 70.1 %)

50. Liu TZ. (1991) Simultaneous presence of three of more usual and atypical creatine kinase isoenzymes in patient serum. J Formosan Med assoc 91:1021-1023. (SCI IF= 1.0; Rank= 51.7 %)

※51. Chiu DTY, Lai KM, Xu CM, Liour SS, Lee J, Liu TZ. (1993) Direct alteration of erythrocyte membrane properties by 1-chloro-2, 4-dinitrobenzene without oxidant challenge. Experimental Hematology 21: 114-118. (SCI IF= 2.91; Rank= 37.2 %)

  1. Chiu DTY. Zuo L, Chen E, Louie E, Lubin B, Liu TZ, and Du CS. (1993) Molecular characterization of G6PD deficiency in patients of Chinese descent and identification of new base substitutions in human G6PD gene. Blood 81:2150-2154. (SCI IF= 9.06 ; Rank= 4.5 %)
  2. Wei JS, Chung Nc, Wei LL, Tseng WF. Liu TZ, and Wang JY. (1993) High molecular weight alkaline phosphatase as a tumor marker for colorectal cancer; comparison of the two methods. Clin Chem 39:540-543. (SCI IF= 7.15; Rank= 3.2 %)

※54. T. Z. Liu, and S. Lee. (1994) Rapid spectrophotometric method for quantitation of acetaminophen (Tyleno) in urine. J Biomed Lab Sci 6:22-28. (Non-SCI)

※55. T. Z. Liu, T. F. Lin, I. J. Hong, J. S. Wei, and D. T. Y. Chiu. (1994) Enhanced susceptibility of erythrocytes deficient in G6PD to alloxan/ glutathione- induced decrease in red cell deformability. Life Sci 55: PL 55-60. (SCI IF= 2.56; Rank= 41.2 %)

56. J. S. Wei, W. L. Ho, R. S. Chang, T. Z. Liu, K. C. Tsao, C. F. Sun, Y. K. Soong, and Y. F. Liaw. (1994) Characterization of the heterogeneity of human alpha-fetoprotein by isoelectric focusing electrophoresis. J Biomed Lab Sci 6:60-64. (Non-SCI)

57. T. Z. Liu, P. Y. Chen, D. T. Y. Chiu, J. S. Wei, K. S. K. Chang and K. H. Lin. 5

(A)REFEREED PAPER
※ Denoted publication related to the fields of free radical, redox biology & antioxidants

(1994) Detection of a novel lactate dehydrogenase isoenzyme and an apparent differentiation-associated shift in isoenzyme profile in hepatoma cell lines. Cancer Letters 87: 193-198. (SCI IF= 4.26; Rank=25 %)

※58.T. Z. Liu, and R. C. Magcauas (1995) Rapid quantitation of serum acetaminophen by direct acid ferric reduction method using a centrifugal analyzer. J Biomed Lab Sci 7:9. (Non-SCI)

※59. M. L. Cheng, I. J. Hung, S. C. Tsai, J. S. Wei, T. Z. Liu and D. T. Y. Chiu (1995) Decrease plasma levels of vitamin A C and E in G6PD-deficient individuals. J Biomed Lab Sci 7:31-38. (Non-SCI)

60. J. Cheng, K. W. Lam, M. Liu and T. Z. Liu. (1995) Development of a monoclonal antibody-based enzyme-linked immunosorbent assay for the quantitation of prostatic acid phosphatase J Biomed Lab Sci 7:91-98. (Non-SCI)

※61. T. Z. Liu, H. L. Yang, C. P. Chan, W. L. Pan, S. K. Wu. (1996) Distinct disparity in the induction of superoxide dismutase isozymes by tumor necrosis factor-α and lipopolysaccharide in culture normal and dilantin-induced hyperplastic gingival fibroblasts. J Formos Med Assoc 95:236. (SCI IF= 1.0; Rank= 51.7 %)

62. M. Liu, G. R. Wang, T. Z. Liu and K. J. Tsai. (1996) Improved fluorometric quantitation of urinary xanthurenic acid. Clin Chem 42:397-400. (SCI IF= 7.15; Rank= 3.2 %)

※63. D. T. Chiu, J. V. D. Berg, F. A. Kuypers, I. J. Hung, J. S. Wei and T. Z. Liu. (1996) Correlation of membrane lipid peroxidation with oxidation of hemoglobin variants: possibly related to the rates of hemin-release. Free Rad Biol & Med 21:89-95. (SCI IF= 5.27; Rank= 14 %)

※64.Tsai K. J., L. Y. Shin, I. J. Hong, S. W. Huang, J. S. Wei, T. Z. Liu & T. Y. Chiu. (1996) Enhanced vesiculation exacerbates complement-dependent hemolysis in glucose-6-phosphate dehydrogenase deficient red blood cells. Life Sci 59:867-876. (SCI IF= 2.56; Rank= 41.2 %)

  1. J. S. Wei, H. C. Cheng, D. H. Liu, D. T. Y. Chiu and T. Z. Liu (1996) Purification and characterization of endogenous digitalis-like compounds in chicken blood. Life Sci 59:1617-1629. (SCI IF= 2.56; Rank= 41.2 %)
  2. L. Palagi, W. S. Lan, G. Juon and T. Z. Liu (1996) The clinical efficacy of a rapid spectrophotometric screenging method for the measurement of total phenolic

6

(A)REFEREED PAPER
※ Denoted publication related to the fields of free radical, redox biology & antioxidants

compounds in urine. J Biomed Lab Sci 8:65-71. (Non-SCI)

※67. T. Z. Liu, T. F. Lin, D. T. Y. Chiu, K. J. Tsai and A. Stern (1997) Palladium or platinum exacerbates hydroxyl radical-mediated DNA damage. Free Rad Biol & Med 23:155-161. (SCI IF= 5.27; Rank= 14.0 %)

※68. D. T. Y. Chiu, T. Y. Huang, I. J. Hung, J. S. Wei, T. Z. Liu and A. Stern. (1997) Hemin-induced membrane sulfhydryl oxidation; possible involvement of Thiyl radicals. Free Rad Res 27:55-62. (SCI IF= 3.28; Rank= 38.6 %)

  1. J. S. Huang, J. K. Chen, W. L. Pan, R. S. Bhatnagar and T. Z. Liu. (1997) Fibroblast derived from tissue explants of dilantin-induced gingival hyperplasia and from idiopathic gingival fibromatosis show distinct disparity in proliferative responsiveness to epidermal growth factor. Kaohsiung J Med Sci 13:598. (Non-SCI)
  2. L. Y. Tsai, K. T. Lee. S. M. Tsai. H. Y. Chen and T. Z. Liu (1997) Plasma amino acid profile in experimental obstructive jaundice of rate. J Biomed Lab Sci 9:27-33. (Non-SCI)
  3. A. Y. Cheng, J. T. C. Chang, G. Juan and T. Z. Liu (1997) Diagnostic efficacy of a monoclonal antibody-based sandwich enzyme linked immunosorbent assay procedure for quantitation of prostatic acid phosphatase in serum. J Biomed Lab Sci 9:23-26. (Non-SCI)
  4. C. N. Ou and T. Z. Liu (1997) Diagnosis of hemoglobinopathies by a weak cation-exchange HPLC. J Biomed Lab Sci 9:1-5. (Non-SCI)

73. T. Z. Liu (1997) Suitability of thymol-preserved standards for the quantitation of protein in serum by three most popular method compared. J Biomed Lab Sci 9:55-60. (Non-SCI)

74.J. S. Wei, J. T. Deng, J. Y. Wang, C. F. Sun, D. T. Y. Chiu, and T. Z. Liu (1997) Monoclonal antibody-based immunocatalytic assay for high-molecular-weight alkaline phsophatase in serum of patients with colorectal cancer. J Biomed Lab Sci 9:73-77. (Non-SCI)

※75. C. F. Chen, W. S. Lan. A. M. Lee and T. Z. Liu (1997) Methylene blue interference with Olympus Reply analyzer determination of serum creatinine concentration. J Biomed Lab Sci 9:68-72. (Non-SCI)

76.P. C. Suen, K. C. Tsao, T. L. Wu, H. C. Ning, T. Z. Liu and S. R. Shih (1997) 7

(A)REFEREED PAPER
※ Denoted publication related to the fields of free radical, redox biology & antioxidants

Reverse transcriptase-polymerase chain reaction for amantadine susceptibility testing of influenza viruses. Biotech Tech. 11:873-878.

※77. D. T. Y. Chiu and T. Z. Liu (1997) Free radical and oxidative damage in human blood cells. J Biomed Sci 4:256-259. (SCI IF= 2.46; Rank= 47.1 %)

※78. T. Z. Liu, C. J. Yuon, H. W. Lo and D. T. Y. Chiu (1997) Enhanced susceptibility to palladium and platinum-induced oxidative damage by human diabetic erythrocytes. J Biomed Lab Sci 9:115-122. (Non-SCI)

79. A. H. P. Liu, and T. Z. Liu (1997) A rapid fluorometric method for measurement of adenosine monophosphate deaminase activity. J. Biomed Lab Sci 9:131-136. (Non-SCI)

※80. H. W. H. Lee, H. S. L. Chen, P. T. Y. Chiu, and T. Z. Liu (1997) Antioxideant imbalance in the aqueous humors of patients with acute anterior uveitis. J Biomed Lab Sci 9:137-145. (Non-SCI)

※81. T. Z. Liu, H. S. L. Chen and H. W. H. Lee (1997) Total lactate dehydrogenase activity and its isoenzyme distribution in aqueous humor of patients with acute anterior uveitis. J. Biomed Lab Sci 9:155-161. (Non-SCI)

※82.T. Z. Liu, and D. T. Y. Chiu (1997) Exogenously administered Superoxide dismutase causes an anomalous shift of the deformability profile of alloxan-glutathione-treated human erythrocytes. J Biomed Lab Sci 9:169-175. (Non-SCI)

※83. T. Y. Chang, M. J. Chang, Y. J. Tsai, and T. Z. Liu (1997) Alteration of erythrocyte deformability profile and morphology by Fenitrothion. J Biomed Lab Sci 9:176-183. (Non-SCI)

※84. T. Z. Liu, S. S. Liu, J. S. Wei and D. T. Y. Chiu (1997) A rapid and simple spectrophotometric method for hydroxyl radical detection. J Biomed Lab Sci 9:94-102. (Non-SCI)

※85. L. Y. Tsai, K. T. Lee and T. Z. Liu (1998) Evidence for accelerated generation of hydroxyl radicals in the experimental obstructive jaundice in rat. Free Rad Biol & Med 24:732-737. (SCI IF=5.27; Rank= 14.0 %)

※86. T. Z. Liu, and A. Stern (1998) Assessment of the role of oxidative stress in human disease. J Biomed Lab Sci 10:12-28. (Non-SCI)

※87. T. F. Lin, R. F. S. Huang, and T. Z. Liu (1998) Quantification of ascorbic acid in 8

(A)REFEREED PAPER
※ Denoted publication related to the fields of free radical, redox biology & antioxidants

pharmaceutical preparations by analyte-induced quenching of xanthurenic acid fluorecscence. J Biomed Lab Sci 10:59-63. (Non-SCI)

※88.T. Z. Liu, L. Y. Chou and M. H. Humphreys (1998) Inhibition of intestinal succinate dehydrogenase by cadmium and palladium ions. J Biomed Lab Sci 10:100-3. (Non-SCI)

※89.B. A. Holcomb, D. C. H. Juan, and T. Z. Liu (1998) Interference of thiol-containing compounds in biochemical tests that use peroxide and peroxidase to generate chromophore: Examplified by enzymatic cholesterol and glucose assays. J Biomed Lab Sci 10:144-150. (Non-SCI)

90.S. N. Tseng, D. Juan and T. Z. Liu (1998) An improved fluorometric method for rapid quantitation of salicylate in serum. J Biomed Lab Sci 10:188-193. (Non-SCI)

※91. J. Wang, D. T. Y. Chiu and T. Z. Liu (1998) Spectrophotometric assay for catalase activity based on the inhibition of peroxidase-catalyzed oxidative coupling indicator reaction. J Biomed Lab Sci 10:200-203. (Non-SCI)

※92. T. Z. Liu, A. Stern and J. D. Morrow (1998) The isoprostanes: unique bioactive products of lipid peroxidation-an overview. J Biomed Sci 5:415-420. (SCI IF= 2.46; Rank= 47.1 %)

※93.R. F. S. Huang, Y. H. Ho, H. L. Lin, J. S. Wei and T. Z. Liu (1999) Folate deficiency induces a cell cycle-dependent apoptosis in HepG2 cells. J Nutri 129: 25-31. (SCI IF= 4.2; Rank= 13.2 %)

※94.T. Z. Liu, A. Stern and Ingrid Emerit (1999) Clastogenic factors: biomarkers of oxidative stress of potential utility in the clinical chemistry laboratory. Annals Clin Lab Sci 29:134-139. (SCI IF= 0.88; Rank= 71 %)

95.L. Y. Tsai, M. F. Hou, S. M. Tsai, T. Z. Liu, and T. J. Huang (1999) Biochemical tumor markers for the breast cancer compared. J Biomed Lab Sci 11: 6-10. (Non-SCI)

96.M. S. Morshedi and T. Z. Liu (1999) On-site diagnostic screening of acute pancreatitis and other acute abdominal disease by a simple instrument-free fluorescence spot test on a filter paper for amylase. J

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Biomed Lab Sci 11:11-15. (Non-SCI)

※97.M. S. Yang and T. Z. Liu (1999) Rapid screening of the presence of palladium ions in water with the use of, as the binding agent and confirmation by reverse-phase ion pair liquid chromatography. J Biomed Lab Sci 11:16-19. (Non-SCI)

※98.T. Z. Liu (1999) Determination of dopamine β-hydroxylase activity by tritium release technique using tritiated tyramine as substrate. J Biomed Lab Sci 11:20-24. (Non-SCI)

99.W. S. Lan, L. Y. Tsai, C. G. Ker, H. W. Lo, C. J. Yuan and T. Z.Liu (1999) Unusual serum creatine kinase isoenzyme pattern associated with a case of hepatocellular carcinoma. J Biomed Lab Sci 11: 25-28. (Non-SCI)

100.M. L. Cheng, T. Z. Liu, F. J. Lu and D. T. Y. Chiu (1999) Simultaneous detection of vitamin C and uric acid in normal and abnormal human aqueous humor and plasma samples by capillary electrophoresis Clinical Biochem 32: 473-476. (SCI IF= 2.45; Rank= 25.8 %)

  1. C. H. Tsai, and T. Z. Liu (1999) Microfluorometric spot test on filter paper for rapid screening of abnormally elevated total creatine kinase activity in serum. J. Biomed Lab Sci 11: 59-64. (Non-SCI)
  2. C. H. Tsai, and T. Z. Liu (1999) A visual pre-screening of a “hooked” (antigen excess) specimen to prevent costly repeated analyses of β-HCG quantitation utilizing two-site immunoradiometric assay. J Biomed Lab Sci 11: 65-69. (Non-SCI)

※103.T. Z. Liu, A. Stern L. J. Roberts, J. D. Morrow (1999). The isoprostanes: Novel prostaglandin-like products of the free radical-catalyzed peroxidation of arachidonic acid. J Biomed Sci 6: 226-235. (SCI IF= 2.46; Rank= 47.1 %)

104.T. Z. Liu, H. W. Lo and K. T. Lee (1999) On-site diagnostic discrimination of acute pancreatitis and other acute abdominal disease at emergency room by a rapid and specific ELISA testing panel of pancreatic amylase and lipase. J Biomed Lab Sci. (Non-SCI)

※105. R. F. S. Huang, H. L. Lin, Y. H. Ho, C. M. Yang and T. Z. Liu (1999) 10

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Nutritional folate depletion promotes apoptotic propensity with perturbing calcium homeostasis in human Hep G2 cells. J Biomed Lab Sci 11:71-77. (Non-SCI)

※106.T. Z. Liu, C. H. Tsai and S. P. Huang (1999) Positive Interference of Xanthurenic acid with quantitation of urinary uric acid by the uricase method. J. Biomed lab Sci 11: 118-124.(Non-SCI)

107. C. W. Huang, T. Z. Liu, K. H. Lee, C. F. Tu, W. C. Lee, T. Shimogiri, H. Mannen, and S. S. L. Li (2000) DNA cloning of pig testicular lactate dehydrogenase-c, thermal stability of the expressed enzyme, and polymorphism among strains. Gene 242: 151-154. (SCI IF= 2.2; Rank= 61.5 %)

※108.T. Z. Liu, C. C. Hu, Y. H. Chen A. Stern and J. T. Cheng (2000) Differentiation status modulates transcription factor NF-kB activity in unstimulated human hepatocellular carcinoma cell lines. Cancer Letters 151: 49-56. (SCI IF= 4.26; Rank= 25.0%)

※109.S. N. Jeng, M. K. Shih, C. M. Kao, T. Z. Liu and S. C. Chen (2000) Antimutagenicity of ethanol extracts of Bee Glue against environmental mutagens. J Food Chem Toxicol. 38: 893-897. (SCI IF= 3.0; Rank= 9.7 %)

110.T. Z. Liu and C. H. Tsai (2000) Palladium ions falsely elevates digoxin levels as determined by the radioimmunoassay procedure via interference with the antigen-antibody binding capacity. J Biomed Lab Sci 12: 7-10. (Non-SCI)

※111.T. Z. Liu (2000) Hyperuricemic phenomenon may be an obligatory response mechanism to counteract oxidative stress in disease. J Biomed Lab Sci 12: 16-19. (Non-SCI)

※112.M. J. Lin and T. Z. Liu (2000) Fluorometric quantitation of glutathione using dibromobimane (thiolyte) as an fluorogenic label. J Biomed Lab Sci 12: 25-30. (Non-SCI)

※113.T. Z. Liu and C. L. Chern (2000) Ascorbate and urate promote paraquat /hydrogen peroxide mediated production of hydroxyl radical. J Biomed Lab Sci 12: 57-61. (Non-SCI)

※114. T. Z. Liu and C. H. Tsai (2000) Generation of superoxide radicals by 11

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human serum containing methylglyoxal: A mechanistic interpreation. J Biomed Lab Sci 12: 62-64. (Non-SCI)

※115. T. Z. Liu, M. L. Cheng and Chin-Hung Tsai (2000) Chemiluminescent evidence that the autoxidation of epinephrine at an elevated pH generates superoxide radical, hydrogen peroxide and hydroxyl radical. J Biomed Lab Sci 12: 79-82. (Non-SCI)

※116.T. Z. Liu, D. T. Y. Chiu, C. H. Tsai and A. Stern (2000) Direct alteration of erythrocyte membrane properties by palladium and platinum ions. J Biomed Lab Sci 12: 113-119. (Non-SCI)

※117.T. Z. Liu, D. T. Y. Chiu and A. Stern (2001) Diethylenetriamino- pentaacetic acid is unsuitable for long-term preservation of red cells. Transfusion 41:556-559. (SCI IF= 3.5; Rank= 32.8%)

※118.C. H. Tsai, A. Stern, J. F. Chiou, C. L. Chern and T. Z. Liu (2001) Rapid and specific detection of hydroxyl radical using an ultraweak chemiluminescence analyzer and a low-level chemiluminescence emitter: Application to hydroxyl radical-scavenging ability of aqueous extract of food constituents. J Arg Food Chem 49: 2137-41. (SCI IF= 2.91; Rank= 1.8%)

※119.C. L. Chern, C. J. Yu, C. H. Tsai and T. Z. Liu (2001) Periodate-catalyzed oxidative coupling of aniline-derived p- aminophenol with p-xylenol as a detection method for hydroxyl radicals. Anal Letts 34: 2477-2484. (SCI IF= 1.0; Rank= 76.0%)

※120.J. T. Afshari and T. Z. Liu (2001) Rapid spectrophotometric method for the quantitation of acetaminophen in serum. Anal Chim Acta 443: 165-169. (SCI IF= 4.39; Rank= 9.3%)

※121. T. Z. Liu, K. T. Lee, C. L. Chern, J. T. Cheng, A Stern and L. Y. Tsai (2001) Free radical triggered hepatic injury of experimental obstructive jaundice of rats is mediated via the overproduction of proinflammatory cytokines and enhanced activation of nuclear factor kB. Ann Clin Lab Sci 31:383-390. (SCI IF= 0.88; Rank= 71.0%)

※122. R. F. S. Huang, S. M. Huang, B. S. Lin, J. S. Wei and T. Z. Liu (2001) Homocysteine thio lactone induces apoptotic DNA damage mediated by increased intracellular hydrogen peroxide and caspase 3 activation

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in HL-60 cells. Life Sci 68: 2799-2811. (SCI IF= 2.56; Rank= 41.2%)

※123. T. Z. Liu (2001) A specific fluorometric method for the detection of hydroxyl radical. J Biomed Lab Sci 13: 33-37. (Non-SCI)

※124. T. Z. Liu, J. Wang and D. T. Y. Chiu (2001) Inhibition of superoxide dismutase and catalase activities by palladium and platinum ions. J Biomed Lab Sci 13: 43-48. (Non-SCI)

  1. ※125.  W. S. Lan, H. W. Lo, G. J. Kerr and T. Z. Liu (2001) Clinical utility of tumor marker CA 72-4 for the diagnosis of colorectal and gastric cancers. J Biomed Lab Sci 13: 49-51. (Non-SCI)
  2. ※126.  Y. H. Chen, R. F. S. Huang, J. S. Wei and T. Z. Liu (2001) Folate deficiency-mediated downregulation of intracellular glutathione and antioxidant enzymes increases susceptibility of human hepatoma Hep G2 cells to various oxidant stress-induced cytotoxicty. J Biomed Lab Sci 13: 52-57. (Non-SCI)

※127.C. L. Chern, R. F. S. Huang, Y. H. Chen, J. T. Cheng and T. Z. Liu (2001) Folate deficiency-induced oxidative stress and apoptosis are mediated via homocysteine-dependent overproduction of hydrogen peroxide and overexpression of NF-kB in human Hep G2 cells. Biomed Pharmacotherapy 55: 434-442. (SCI IF= 2.07; Rank= 55.8%)

※128. H. L. Yang, S. H. Wang, C. P. Chan and T. Z. Liu (2001) Upregulation of antioxidant defenses in TNF-treated NifRdipine transformed gingival hyperplastic fibroblasts by selective overexpression of MnSOD. J Biomed Lab Sci 13: 70-77. (Non-SCI)

129. S. M. Ing, P. F. Lu and T. Z. Liu (2001) Novel fluorometric determination of biotinidase activity in serum. J Biomed Lab Sci 13: 78-82. (Non-SCI)

※130. Y. T. Hsu, I. S. Hong, T. Y. Wu and T. Z. Liu (2001) Direct alteration of erythrocyte membrane properties by eugenol. J Biomed Lab Sci 13: 83-89. (Non-SCI)

※131.J. H. Chen, C. H. Tsai, T. Z. Liu and S. C. Chen (2001) Antioxidant action of tannic acid and its related compounds: Their interaction with superoxide anion, hydroxyl radical and complexation abilities with ferrous ions. J Biomed Lab Sci 13: 6-10. (Non-SCI)

※132. L. Li, C. H. Tsai, W. C. Lo and T. Z. Liu (2001) Green tea polyphenols ameliorate hydroxyl radical-mediated DNA strand breakages. J Biomed Lab Sci 13: 104-107.

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(Non-SCI)

※133. M. K. Shih, C. H. Chen, T. Z. Liu and M. T. Yau (2001) Exacerbation of UVA-induced mitochondrial dysfunction of human SK-Hep-1 cells by ferrous ions. J Biomed Lab Sci 13: 128-132. (Non-SCI)

134. C. W. Chen, Y. C. Chen and T. Z. Liu (2001) Redistribution of creatine kinase and lactate dehydrogenase isoenzyme activities in normal rat kidney fibroblasts transformed by temperature-sensitive mutants of avian sarcoma virus. J Biomed Lab Sci 13:99-103. (Non-SCI)

  1. ※135.  Y. C. Hseu, S. Y. Wang, H. Y. Chen, F. J. Lu, R. J. Gau, W. C. Chang, T. Z. Liu and H. L. Yang (2002) Humic acid induces the generation of NO in human umbilical vein endothelial cells: stimulation of NOS during cell injury. Free Rad Biol & Med 32: 619-629. (SCI IF= 5.27; Rank= 14.0%)
  2. ※136.  C. L. Chern, C. F. Chen and T. Z. Liu (2002) Serum vitamin C status in patients

with various pathological conditions determined by enzyme-assisted spectrophotometric method. J Biomed Lab Sci 14: 35-38. (Non-SCI)

※137. C. F. Chen, W. H. Lan, Y. L. Hsieh and T. Z. Liu (2002) Interference of Clinical enzyme assays by methylglyoxal. J Biomed Lab Sci 14: 39-42. (Non-SCI)

138. W. H Lan, C. G. Ker, C. C. Juan and T. Z. Liu (2002) Expression of anomalous creatine kinase and lactate dehydrogenase isoenzymes in C3H mouse carrying human tumors. J Biomed Lab Sci 14:43-46. (Non-SCI)

  1. ※139.  C. L. Wang, C. F. Chen, W. S. Lan, J. J. Huang and T. Z. Liu (2002) High prevalence of hyperuricemia amongst workers with hypertensive or hyperlipidemic conditions in a plastic manufacturing factory and a petroleum refinery of Southern Taiwan: A retrospective appraisal. J Biomed Lab Sci 14: 64-68. (Non-SCI)
  2. ※140.  S. H. Wang, H. L. Yang W. C. Lo and T. Z. Liu (2002) Upregulation of antioxidant defense in nifedipine-transformed gingival fibroblasts confers enhanced resistability to the growth inhibitory effect by nitric oxide-generating compounds. J Biomed Lab Sci 14: 69-74. (Non-SCI)

※141. T. Z. Liu, D. T. Y. Chiu and A Stern (2003) Palladium and platinum ions interfere with the measurement of erythrocyte vesiculation by inhibiting the acetylcholinesterase activity of the released spectrin-depleted microvesicles. Life Sci 72: 909-916. (SCI IF= 2.56; Rank= 41.2%)

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  1. ※142.  C. H. Tsai, R. C. Chang, J. F. Chiou and T. Z. Liu (2003) Improved superoxide- generating system suitable for the assessment of the superoxide-scavenging ability of aqueous extracts of food constituents using ultraweak chemiluminescence. J Arg Food Chem 651: 58-62. (SCI IF= 2.91; Rank= 1.8%)
  2. ※143.  S. C. Chen, C. M. Kao, M. H. Huang, M. K. Shih, Y. L. Chen, S. P. Huang and T. Z. Liu (2003) Assessment of genotoxicity of benzidine and its structural analogues to human lymphocytes using comet assay. Toxicological Sci 72: 283-288. (SCI IF= 4.3; Rank= 9.4%)
  3. ※144.  W. C. Lo and T. Z. Liu (2003) Alleviation of paraquat-induced abnormality in deformability profile of human erythrocytes by sodium salicylate. J Biomed Lab Sci 15: 16-20. (Non-SCI)
  4. ※145.  C. F. Chen, W. S. Lan and T. Z. Liu (2003) Hyperglycemia-mediated decreases in deformability index of erythrocytes as an indicator of oxidative stress due to elevated protein glycation in diabetic patients. J Biomed Lab Sci 15: 40-44. (Non-SCI)

146. G. J. Kerr, W. S. Lan H. T. Chien and T. Z. Liu (2003) Methylglyoxal interferes with the enzyme immunoassay procedure for quantifying various analytes in serum. J Biomed Lab Sci 15:88-2. (Non-SCI)

  1. ※147.  C. H. Chen, C. L. Chern, C. C. Lin, F. J. Lu, M. K. Shih, P. Y. Hsieh and T. Z. Liu (2003) Involvement of reactive oxygen species, but not mitochondrial permeability transition in the apoptotic induction of human SK-Hep-1 heaptoma cells by Shikonin. Planta Medica 69: 1119-1124. (SCI IF= 2.35; Rank= 28.2%)
  2. ※148.  C. F. Chen, C. H. Tsai, W. C. Lo and T. Z. Liu (2003) Dissecting the structural prerequisites for the antioxidative capability of phenolic compounds and their related derivatives as predicted by direct acid ferric reduction method. J Biomed Lab Sci 15: 99-104. (Non-SCI)
  3. ※149.  T. J. Hsieh, T. Z. Liu, Y. C. Chia, C. L. Chern, F. J. Lu, C. Chung, S. Y. Mau, S. H. Chen, Y. H. Syu, and C. H. Chen (2004) Protective effect of methyl gallate from Toona Sinensis (Meliaceeae) against hydrogen peroxide-induced oxidative stress and DNA damage in MDCK cell. Food and Chem Toxicol 42: 843-850.(co-first author) (SCI IF= 3.0; Rank= 9.7%)

※150.M. H. Lin, W. H. Lan and T. Z. Liu (2004) Arecoline induces cell cycle dysreguation and apoptosis in gingival fibroblasts. J Biomed Lab Sci 16: 16-22.

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(Non-SCI)

  1. ※151.  C. F. Chen, Y. T. Tseng, H. K. and T. Z. Liu (2004) An automated high-throughput spectrophotometric method for urinary p-aminophenol quantitation based on oxidative coupling principle. Annals Clin Lab Sci 34:336-340. (SCI IF= 0.88; Rank= 71%)
  2. ※152.  C. H. Tsai, T. L. Pan, Y. S. Lee, Y. K. Tai and T. Z. Liu (2004) Evidence that high dose L-arginine may be inappropriate for use by diabetic patients as a prophylactic blocker of methylglyoxal glycation. J Biomed Sci 11: 692-696. (SCI IF= 2.46; Rank= 47.1%)
  3. ※153.  C. H. Chen, T. J. Hsieh, T. Z. Liu, C. L. Chern, P. Y. Hsieh and C. Y. Chen (2004) Annoglabayin, a novel dimeric Kaurane diterpenoid and apoptosis on Hep G2 cells

of annomontacin from the fruit of Annona glabra. J Nat Products 67:1942-1946. (SCI IF= 3.29; Rank= 14.9%)

※154. C. H. Chen, T. Z. Liu, T. C. Kuo, F. J. Lu, Y. C. Chen, Y. W. Chang-Chien and C.C. Lin (2004) Casuarinin protects cultured MDCK cells from hydrogen peroxide- induced oxidative stress and DNA damage. Planta Medica 70:1022-1026. (co-first author) (SCI IF= 2.35; Rank= 28.2%)

※155.W. C. Lo, J. F. Chiou , M. H. Lin and T. Z. Liu (2004) Normoxic expression of hypoxia inducible factor 1-αupregulates iron-binding capacity via overexpressing transferring in human hepatoma J5 cells: A possible protective mechanism for free radical-mediated insult. J Biomed Lab Sci 16: 46-50. (Non-SCI)

※156. M. L. Cheng, S. A. Chu, W. C. Lo and T. Z. Liu (2004) Measurement of ascorbate-induced hydroxyl radical generation in household drinking water in Kaohsiung and Taipei Metropolitan areas using fluorescence technique in ELISA format. J Biomed Lab Sci 16: 51-56. (Non-SCI)

157. T. Z. Liu (2004) Palladium toxicity and cardiovascular dysfunction. J Biomed Lab Sci 16: 73-77. (Non-SCI)

※158. T. J. Hsieh, T. Z. Liu, C. L. Chern, D. A. Tsao, F. J. Lu, Y. H. Syu, P. Y. Hsieh, H. S. Hu, T. T. Chang, C. H. Chen (2005) Liriodenine inhibits the proliferation of human hepatoma cell lines by blocking cell cycle progression and nitric oxide mediated activation of P53

16

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expression. Food Chem Toxicol 43:1117-1126. ( SCI IF= 3.0; Rank= 9.7%)

※159.M. L. Cheng, C. H. Tsai, C. W. Chen, W. C. Lo and T. Z. Liu (2005) Inhibition of lucigenin-based ultraweak chemiluminescence generated by the autoxidation of epinephrine as an assay of superoxide dismutase. J Biomed Lab Sci 17:18-23. (Non-SCI)

※160. C. F. Chen, W. H. Lan and T. Z. Liu (2005) Effects of vitamin B12 and thyroid powder on estrogen-mediated expression of uterine protocollagen proline hydroxylase by the ovariectomized rats. J Biomed Lab Sci 17:24-28. (Non-SCI)

※161.T. J. Hsieh, T. Z. Liu, F. J. Lu, P. Y. Hsieh and C. H. Chen (2006) Actinodaphnine induced apoptosis through increased nitric oxide, Reactive oxygen species and down-regulation of NF-κB signaling in human hepatoma Mahlavu cells. Food Chem Toxicol 44:344-354. (SCI IF= 3.0; Rank= 9.7%)

162. H. R. Cheng, T. L. Cheng, T. Z. Liu, H. S. Hu, L. S. Hsu, W. C. Tseng, C. H. Chen and D. A. Tsao (2006) Genetic and cellular characterization of human TCF4 with microsatellite instability in colon cancer and leukemic cell lines. Cancer Letts 233:165-171. (SCI IF= 4.26; Rank= 25.0%)

※163. T. Z. Liu, C. Y. Chen, S. J. Yiin, C, H. Chen, J. T. Cheng, M. K. Shih, Y. S. Wang and C. L. Chern (2006) Molecular mechanism of cell cycle blockage of human SK-Hep-1 cells by Epimedin C through suppression of mitogen-activated protein kinase activation and increased expression of CDK inhibitors P21cip1 and P27kip1. Food Chem Toxicol 44:227-235. (SCI IF= 3.0; Rank= 9.7%)

※164.C. H. Wang, T. Z. Liu, S. M. Chye, F. J. Lu, Y. C. Liu, Z. C. Lin and C. H. Chen (2006) Sevoflurane-induced oxidative stress and cellular injury in human peripheral polymorphonuclear neutrophils. Food and Chem Toxicol 44:1399-1407. ( SCI IF= 3.0; Rank= 9.7%)

※165.C. W. Chen, J. F. Chiou, C. H. Tsai, C. W. Shu, M. H. Lin, L. Y. Tsai and T. Z. Liu (2006) Development of probe-based ultraweak chemiluminescence technique for the detection of a panel of four oxygen-derived free radicals and their application in the assessment

17

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of radical-scavenging abilities of extracts and purified compounds from food and herbal preparations. J Agr Food Chem 54: 9297-9302. (SCI IF= 2.91; Rank= 1.8%)

※166.S. H. Kuo, T. Z. Liu, Y. W. Lin, W. C. Tseng, R. H. Liu, F. J. Lu, Y. S. Lin, C. Y. Chen, C. H. Chen (2007) 6-shogaol (alkanone from Ginger) induces apoptotic cell death of human hepatoma p53 mutant Mahlavu subline via an oxidative stress mediated caspase-dependent mechanism. J. Arg Food Chem 55: 948-954. (co-first author) (SCI IF= 2.91; Rank= 1.8%)

※167. D. Zhao, T. Z. Liu, E. C. Chan, H. Fein, Xueji Zhang(2007) A novel enzymatic method for determination of homocysteine using electrochemical hydrogen sulfide sensor. Frontier in Bioscience 12:3774-3780. (co-first author) (SCI IF= 3.286; Rank= 37.9%)

※168.C. H. Chen, T. Z. Liu, C. H. Chen, C. H. Wong, F. J. Lu and S. C. Chen (2007) Protective effects of tannic and its related compounds against hydrogen peroxide-induced oxidative stress and DNA damage in IMR-90 cells. Mol Nutri Food Res 51:962-968. (co-first author) (SCI IF= 4.31; Rank= 3.2%)

※169. C. Y. Chen, T. Z. Liu, C. H. Chen, S. J. Yiin, J. T. Cheng, M. K. Shih, M. J. Wu, C. L. Chern (2007) Isoobtusilactone A-induced apoptosis in human hepatoma Hep G2 cells is mediated via increased NADPH oxidase-derived reactive oxygen species (ROS) production and the mitochondria-associated apoptotic mechanisms. Food Chem Toxicol 45:1268-1276.(SCI IF= 3.0; Rank= 9.7%)

※170.T. K. Er, S. M. Tsai, S. H. Wu, W Chiang. H. C. Lin, S. F. Lin, S. H. Wu, T. Z. Liu, L. Y. Tsai (2007) Antioxidant stantus and superoxide anion radical generation in acute myeloid leudemia. Clin Biochem 40:1015-1019. (co-corresponding author) (SCI IF= 2.45; Rank= 25.8%)

※171M. D. Woon, Y. H. Wang, H. W. Lo, D. Chung, T. Z. Liu and J. F Chiou (2007) The effect of hepatoma-derived growth factor, Bcl-2 and glutathione on radication-induced apoptosis in hepatocellular carcinoma cell lines. Ther Rad Oncol 14:179-188. (Non-SCI)

※172.T. Z. Liu, J. T. Cheng, S. J. Yiin, C. Y. Chen, C. H. Chen, M. J. Wu and C. L. Chern (2008) Isoobtusilactone A induces both caspase-

18

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dependent and -independent apoptosis in Hep G2 cells. Food Chem Toxicol 46:321-327. (SCI IF= 3.0; Rank= 9.7%)

※173.S. N. Wang. T. Z. Liu, Y. L. Chen and D. Shiuan (2007) Protective effects of a freeze-dried extract of vegetables and fruits on the hydroxyl radical-mediated oxidative damage of DNA and decrease of erythrocyte deformability. Appl Biochem Biotech 141:241-250. (SCI IF= 1.89; Rank= 54.1%)

※174.C. P. Lin, Y. H. Chen, J. W. Chen, H. B. Leu, T. Z. Liu and S. L. Huang (2008) Cholestin (Monasous purpureus Rice) Inhibits Homocystein-induced reactive oxygen species generation, Nuclear Factor-κB activation, and vascular cell adhesion molecule-1, expression in human aortic endothelial cells. J Biomed Sci.15:183-196. (SCI IF= 2.46; Rank= 47.1%)

※175. C. P. Lin, Y. H. Chen, W. T. Lin, H. B. Leu, T. Z. Liu, S. L. Huang and J.W.Chen (2008) Direct effect of statin on homocysteine-induced endothelial adhesiveness:Potential impact to human atherosclerosis. Euro J Clin Invest 38:106-116. ( SCI IF= 3.37; Rank= 15.2%)

※176.J. F. Chiou, S. L. Chen, S. M. Chen, S. S. Tsou, C. Y. Wu, J. S. Chu and T. Z. Liu (2008) Novel spectrophotometric method for rapid quantifying acetaminophen concentration in emergent situation. J Food Drug Anal 16:36-40. (SCI IF= 0.33; Rank= 84.7%)

※177.C. Y. Chen, T. Z. Liu, W.C. Tseng, F. J. Lu, R. P. Hung, C. H. Chen, and C. H. Chen (2008) (-)-Anonaine induces apoptosis through Bax-and caspase-dependent pathways in human cervical cancer (HeLa)cells. Food and Chem Toxicol 46:2694-2702.(co-first author) (SCI IF= 3.0; Rank= 9.7%)

※178.L.Y. Tsai, J. N. Tung, T. Z. Liu(2008) Distinct disparity in the induction of stimulus-mediated superoxide generation by the polymorphonuclear neutrophils isolated from different types of leukemia. J Formos Med Assoc 107: 513-518. (SCI IF= 1.0; Rank= 51.7%)

※179.T. Z. Liu (2009) The unfolded protein response (uPR): A new paradigm in cancer research. Tungs’ Med J 3:1-6. (Non-SCI)

※180.J. F. Chiou, Y. H. Wang, M. J. Jou, T. Z. Liu and C. Y. Shiau (2009) 19

(A)REFEREED PAPER
※ Denoted publication related to the fields of free radical, redox biology & antioxidants

Verteporfin-photoinduced apoptosis in Hep G2 cells is mediated by Reactive oxygen and nitrogen species intermediates. Free Rad Res 44:155-170. (SCI IF= 3.28; Rank= 38.6%)

※181. J. F. Chiou, C. J. Tai, Y. H. Wang, T. Z. Liu, Y. M. Jen and C. Y. Shiau (2009) Sorafenib induces preferential apoptotic killing of a drug-and radio-resistant Hep G2 cells through a mitochondria- dependent oxidative stress mechanism. Cancer Biol Ther 8 : 1904-1913. (SCI IF= 3.28; Rank= 38.3%)

※182.J. F. Chiou, C. J. Tai, Y. H. Wang, T. Z. Liu and Y. J. Cheng (2010) Glucose-regulated chaperone protein-78 is a novel contributor to the occurrence of resistance acquisition of Sorafenib, a multi-kinase inhibitor, in hepatoma cells. Ann Surg Oncology 17: 603-612. (SCI IF= 4.12; Rank= 4.5%)

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